Testosterone Enanthate is a derivative of the primary endogenous androgen testosterone, for intramuscular administration. In their active form, androgens have a 17-beta-hydroxy group. Esterification of the 17-beta-hydroxy group increases the duration of action of testosterone; hydrolysis to free testosterone occurs in vivo. Testosterone Enanthate was first synthesized by being isolated from an animal source in 1935.
Testosterone Enanthate is the most popular form of testosterone prescribed everywhere in the world except for the United States, where the very similar Testosterone Cypionate is typically preferred.
Testosterone Enanthate is designated chemically as androst-4-en-3-one, 17-[(1-oxoheptyl)-oxy]-, (17β)-.
Testosterone exerts both genomic and non-genomic effects in the human body. This means that while many of testosterone’s effects are mediated by the androgen receptor, and gene transcription, many also occur without such stimulation. Testosterone promotes health and well-being, enhances libido, increases energy and promotes fat loss. Testosterone can also boost immunity. Testosterone aids in gaining and preserving lean muscle mass. Testosterone prevents against bone loss as well as heart disease.
Testosterone Enanthate has a release time of between 8-10 days. Testosterone Enanthate is typically injected once every one to three weeks, though some users opt for a twice a week frequency as well. This version of testosterone will cause the usual side effects associated with Testosterone, including: hair loss, acne, gynecomastia and eventual cessation of the body’s natural testosterone production. Many of these side effects can be associated (if not totally attributed) with the conversion of Testosterone into Dihydrotestosterone and estrogen.
Overall, the most common effect reported by subjects using Testosterone Enanthate is gains in strength and typically, testosterone is implicated in positive alterations in size, shape, and appearance of muscle.
Due to stimulation of the Androgen Receptors (AR), accelerated muscle gain, fat loss, increased muscle repair and growth is experienced by those using injectable Testosterone Enanthate. Testosterone Enanthate can also binds to the Androgen Receptors on fat cells; therefore, adipose (fat) tissue can be broken down more readily and new fat formation is prevented. It is thought, therefore, that many of Testosterone Enanthate effects are receptor mediated; although many effects are also non-receptor mediated.
While using injectable Testosterone Enanthate, since the body is building muscle at an accelerated rate, more foodstuffs are shuttled directly to the muscle tissue (this is known as nutrient portioning) and away from fat. This is another indirect effect of Testosterone Enanthate on fat loss. Testosterone Enanthate also promotes glycogen synthesis, which is activated by insulin in response to high glucose levels, thus allowing someone using testosterone to more efficiently utilize food as fuel.
Testosterone’s anabolic/androgenic effects are dependant upon the dose administered; usually the higher the dose, the better the results. Testosterone Enanthate probably no different than testosterone cypionate (another long acting form of testosterone). In a study done on Testosterone Enanthate, a dose as high as 600 mg’s produced better results in subjects compared to those who received lower doses. The most fat was lost and lean body mass, strength and size was gained by the group who used the highest dose (600 mg/week), when compared to any of the lower doses studied. But Testosterone Enanthate allows for once a week beginners and can be found on the online market in doses anywhere from 200-500 mg/ml for a period of 10 weeks with very good results.
Personally I have used this form of testosterone on many occasions. Although I prefer the shorter esters, Testosterone Cypionate is probably the cheapest form of testosterone that can be found on the online market, and that has influenced my choice to use it more than once.
Water retention with Testosterone Enanthate often requires some kind of anti-estrogen to combat it (for me, anyway), although I seem to be able to handle pretty high doses without having any other problems with bloodwork or gyno.
Most people will find that 500-1000 mg Testosterone Enanthate is going to be more than enough to build tons of new muscle. My own personal anabolic routine (doctor prescribed) rarely has me going over 500mg Testosterone Enanthate, and I typically feel that 750 mg of enanthate are also excellent for creating clear results within a 10 week period. More advanced athletes and professional bodybuilder will often stack testosterone with dianabol, deca-durabolin, primobolan or equipose to create a powerful mass building stack.